▍ Prof. CHEN Xiaoyuan, Shawn
Appointment
Professor
Shandong Provincial Key Laboratory of Precision Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences
E-mail: chen9647@gmail.com

NIH Research Festival Plenary Session II
- New Insights Through Clinical Imaging
▍ News
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课题组因科研工作与临床转化发展需要,现面向全球公开招聘博士后研究人员若干名。 一、导师及项目简介 陈小元(Shawn Chen)教授是纳米医学、分子影像及生物材料领域的国际顶级专家,欧洲科学院、欧盟科学院、新加坡国家科学院院士。发表SCI论文1200余篇(引用近18万次,H指数219),连续多年入选科睿唯安“全球高被引科学家”;研究成果多次在国际顶级期刊发表。团队核心研究方向为可临床转化的诊疗一体化技术开发,开创性研发了新型分子影像探针、纳米材料,并将其应用于药物研发、基因治疗、免疫治疗等领域。 陈教授团队依托山东省肿瘤医院与多所海外知名大学开展密切合作。因合作需求,面向全球招聘优秀博士后,旨在培养具有国际视野、能够冲击国家级人才计划的优秀青年学者。 二、招聘条件 (一)已获得或即将获得药学、化学、生物医学工程、分子生物学、核医学、肿瘤学、材料科学、生物化学等相关专业博士学位,博士毕业不超过3年,年龄一般在35周岁以下,品学兼优,身体健康; (二)研究方向与课题组一致或有相关交叉,具有独立开展科研工作的...
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On June 16th, our recently work “A nanovaccine targeting cancer stem cells and bulk cancer cells for postoperative cancer immunotherapy” was published on Nature Nanotechnology (2025, doi: org/10.1038/s41565-025-01952-x). Our laboratory has focused on biomimetic nanovesicle-based drug delivery and immunotherapy. Here we propose a nanovaccine strategy, called NICER, based on a nanovesicle system integrating CSC-specific antigen display and epigenetic nano-regulator encapsulation with a dendritic-cell-targeting aptamer. Specifically, nanovesicles derived from aldehyde-dehydrogenase-overexpressing tumours could serve as integrated antigens carrying both CSC-specific antigen and tumour-associated antigens. Epigenetic nano-regulator targeting YTH N6-methyladenosine RNA binding protein 1 could restrict dendritic cell lysosomal protease activity to modulate...
▍ Selected Publications